A potential hazard: toxicity of zinc with penicillamine
نویسندگان
چکیده
منابع مشابه
Cholestasis due to D-penicillamine toxicity.
A patient with sero-positive rheumatoid arthritis was treated with D-penicillamine (cumulative dose 3 . 7 3 9 . Three weeks after starting therapy she developed a fever, rash and a cholestatic jaundice. Cessation of D-penicillamine resulted in improvement. However, reintroduction of D-penicillamine 1 0 days later (cumulative dose 2g), was followed by acute hepatic failure and death. Liver biops...
متن کاملWithdrawal of penicillamine from zinc sulphate-penicillamine maintenance therapy in Wilson's disease: promising, safe and cheap.
BACKGROUND Penicillamine, once considered the cornerstone of treatment for Wilson disease (WD), is rather expensive and toxic, and often causes neurological worsening. Zinc sulphate, aiming at the treatment of free-copper toxicosis, has emerged as effective, safe and cheap alternative. AIM To assess the effect of withdrawal of penicillamine from maintenance treatment with penicillamine and zi...
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The incidence of penicillamine toxicity was determined in 250 patients who had never previously received gold, 76 patients who had received gold without toxic reaction, and 79 patients with a previous history of gold toxicity. The results suggest that there may be a higher incidence of penicillamine toxicity in patients who have previously shown toxic reactions. The interval between stopping th...
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We report an interesting phenomenon we recently encountered in our hospital. Our patient was a healthy man who came in for an emergency hernia repair due to suspected obstruction. Previous anaesthesia for an orthopaedic operation the previous year had been uneventful. The plan was to anaesthetize him with a rapid sequence induction. This was done in view of the increased risk of aspiration give...
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The evaluation of the nutritional quality of foods and feeds requires a more definite knowledge of the physiological role of the various micro nutrient inorganic elements in the animal body than is now available. Problems of immediate concern include the effects of one or more of these elements on the utilization of another, for example the effect of traces of arsenic in reducing the toxicity o...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1977
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780200428